Scott McCall, a high school student living in the town of Beacon Hills has his life drastically changed when he's bitten by a werewolf, becoming one himself. He must henceforth learn to balance his problematic new identity with his day-to-day teenage life. The following characters are instrumental to his struggle: Stiles, his best friend; Allison, his love interest who comes from a family of werewolf hunters; and Derek, a mysterious werewolf with a dark past. Throughout the series, he strives to keep his loved ones safe while maintaining normal relationships with them.

A frantic call to the CDC has everyone paranoid, especially since it was designed to target werewolves. Scott, Malia and Kira lock themselves in the Hale vault, unaware of their salvation within their grasp.