Teenager Riley's mind headquarters is undergoing a sudden demolition to make room for something entirely unexpected: new Emotions! Joy, Sadness, Anger, Fear and Disgust, who’ve long been running a successful operation by all accounts, aren’t sure how to feel when Anxiety shows up. And it looks like she’s not alone.

Riley, now 12, is hanging out at home with her parents in San Francisco when potential trouble comes knocking: a boy shows up at the door.

Growing up can be a bumpy road, and it's no exception for Riley, who is uprooted from her Midwest life when her father starts a new job in San Francisco. Riley's guiding emotions— Joy, Fear, Anger, Disgust and Sadness—live in Headquarters, the control centre inside Riley's mind, where they help advise her through everyday life and tries to keep things positive, but the emotions conflict on how best to navigate a new city, house and school.

A lazy, incompetent middle school teacher who hates her job and her students is forced to return to her job to make enough money for a boob job after her rich fiancé dumps her.