After a scientific experiment leads to the creation of a clone of Mewtwo, he sets out to destroy the world. Ash and his friends then decide to thwart Mewtwo's evil plans.

This is the story of how Ash and Pikachu first met. At first, Pikachu was disobedient towards Ash, but Ash only wanted to be friends with Pikachu. On the day they set out from Pallet Town, both of them saw a Ho-Oh flying and they made a vow to meet it.