Ruehl received her first Academy Award nomination and win for her performance as Anne Napolitano, the emotionally driven girlfriend to fallen radio personality, (played by Jeff Bridges), in Terry Gilliam's masterpiece, The Fisher King (1991). In addition to an Oscar, and a Golden Globe, Ruehl's performance garnered several accolades. Los Angeles Times commended the performance, calling it "a bravura performance that runs from high, bantering comedy to an intense projection of pain and sorrow." Notable film credits include The Fisher King (1991), Lost in Yonkers (1993) and Roseanna's Grave (1997).