After her parents divorced at the age of three, Brenna Caitlin Otts settled in a rural mountain town in the United States with her mother and sister. It was there that Otts' mother first enrolled her youngest in a local theatre troupe, hoping the experience would make her painfully shy child more comfortable around others. Otts was bitten by the acting bug after that first performance, going on to perform in countless plays and musicals throughout her adolescence. After graduating top of her class, Otts decided to attend Colorado State University to pursue her bachelor's degree in acting. While there, she began her professional career in nearby Denver, snagging her first lead role in a feature film before graduating a year early and moving to Los Angeles. She booked her first network television speaking role on the HBO hit series "Westworld" and began working steadily in the industry from then on out, acquiring her first recurring role on the CBS All Access cult classic "Strange Angel" in 2019.